The Causal Relationship between Type 2 Diabetes Mellitus and Ovarian Cancer: Two-Sample Mendelian randomization

Abstract

Aims: This research aimed at determining the causal relationship between type 2 diabetes mellitus (T2DM) and ovarian cancer using two-sample Mendelian randomization technique. This is because there is an assumption that type 2 diabetes mellitus (T2DM) has a causal relationship with ovarian cancer due to the alarming rising incidence statistics. Study design: This study used a two-sample Mendelian Randomization (MR) design to undertake the causal relationship investigation. Mendelian randomization technique uses genetic variants as instrumental variables, which undergo random allocation at conception and are non-modifiable. This makes it not to be affected by confounding factors and reverse causation. The MR techniques employed are MR-Egger and Inverse Variance Weighted (IVW.) Data sources: The outcome (ovarian cancer) summary statistics was retrieved from Ovarian Cancer Association Consortium (OCAC), which has 66,450 samples (number of cases=25,509, number of controls=40,941) of European population. The exposure (T2DM) summary genetic data